2 - The rise to prominence of Artemisia annual the transformation of a Chinese plant to a global pharmaceutical
African Sociological Review,
Vol. 14 No. 2 (2010): African Sociological Review
Abstract
This paper focuses on the transformation of a recently promoted medicinal plant named
Artemisia annua L. For over 2000 years, the Chinese have used A. annua as a herbal tea preparation against malaria. Pharmacological studies led to the isolation of artemisinin as the principal anti-malarial compound. Since 2001, the World health Organisation (WhO) has recommended artemisinin-based combined therapies (‘ACTs’) for the treatment of malaria – novartis is the leading actor to extract the compound in tablet form. in the 1990s, A. annua was introduced to Tanzania. Beside the local plant-based promotion of Artemisia-tea as an efficient, inexpensive natural practice to treat malaria, Tanzania hosts influential actors who seek to commercialise the plant. By following the biography of the Chinese medicinal plant, its global transfer, production, marketing, distribution, consumption, and its transformation to a highly demanded commodity, the paper critically reveals the dialectics and reciprocities between different actors and their relation to existing powerful reference systems (such as WhO, Pharmaceutical industry).
Keywords
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- Amin, A.A., D.A. Hughes, V. Marsh, T.O. Abuya, G.O. Kokwaro, P.A. Winstanley, S.A. Ochala and R.W. Snow, 2004. The difference between effectiveness and efficacy of antimalarial drugs in Kenya. Tropical Medicine and international health, 9 (9), pp. 967-974.
- Appadurai, A.,1986. The social life of things. Commodities in cultural perspective. Cambridge University Press.
- Arrow, K.J., C.B. Panosian and H. Gelband, 2004. Saving lives, buying time: economics of Malaria Drugs in an Age of Resistance. Institute of Medicine of the National Academies, p. 22-23.
- Bekanis, A., 2004. Making Artesunate available in African countries. An urgent need. 8. Global Forum for health research, Mexico City, 16-20th November 2004. Pharmacology, Geneva University, Switzerland.
- Bhakuni, R.S., D.C. Jain and R.P. Sharma, 2002. Phytochemistry of Artemisia annua and the development of artemisinin-derived antimalarial agents. In: Wright, C.W. (Ed.): Artemisia. London: Taylor & Francis.
- Bilia, A.R., D. Lazari, L. Messori, V. Taglioli, C. Temperini and F.F. Vinvieri, 2002.
- Simple and Rapid physico-chemical methods to examine action of antimalarial drugs with hemin: its application to Artemisia annua constituents. Life Sciences (70), pp. 769-778.
- Bökemeier, R., 2006. Ein Kraut wirkt Wunder. GeO Magazin, Leonardo da vinci (6), 1. 6. 2006.
- Bosman, A. and K.N. Mendis, 2007. A major transition in malaria treatment: the adoption and development of Artemisinin-based combination therapies.
- American Journal of Tropical Medicine and hygiene (77), pp.193-197.
- Chen, J. and T. Chen, 2004. Chinese Medical Herbology and Pharmacology, USA. Art of Medicine Press.
- Chetley, A. and D. Gilbert ,1986. Problem Drugs. HAI/IOCU, The Hague/ Penang.
- Cutler, M., A. Lapkin, and P.K. Plucinski, 2006. Comparative assessment of technologies for extraction of artemisinin. Summary report commissioned through the Malaria Medicines Venture, Geneva.
- Dalrymple, D.G., 2008. Agriculture, Artemisia annua, Artemisinin, ACTs and Malaria control in Africa: The Interplay of Tradition, Science and Public Policy. Workingpaper. Available at < http://artemisia-for-all.org/wordpress/wp-content/uploads/Artemisia_Agr._and_Malaria_in_Afr._ Consolidated no._4-1.pdf > [Accessed 27.4.2010].
- De Ridder, S., F. Van der Kooy and R. Verpoorte, 2008. Artemisia annua as a self- reliant treatment for malaria in developing countries. Journal of ethnopharmacology (120), pp. 302-314.
- Durrheim, D.N. and H.A. Williams, 2005. Assuring effective malaria treatment in Africa: Drug efficacy is necessary but not sufficient. Journal of epidemiology and Community health (59), pp. 178-189.
- Ecks, S., 2008. Global Pharmaceutical Markets and Corporate Citizenship: The Case of Novartis’ Anti-cancer Drug Glivec. BioSocieties 3(2), pp. 165-181.
- Etkin, N.L., 1988. Cultural constructions of efficacy. In: Whyte, S.R. and S. Van der Geest (Eds,): The context of medicines in developing countries.
- Studies in Pharmaceutical Anthropology 3-11. Amsterdam: Het Spinhuis.
- Gessler, M.C., D.E. Msuya, M.H.H. Nkunya, L.B. Mwasumbi, A. Schär, M. Heinrich and M. Tanner, 1995.
- Traditional healers in Tanzania: the treatment of malaria with plant materials. Journal of ethno pharmacology (48), pp. 131-144.
- Guo-Qiao L., G. Xing-Bo, F. Lin-Chun, J. Hua-Xiang and J. Xin-Hua Wang, 1994. Clinical trials of artemisinin and its derivatives in the treatment of malaria in China. Transactions of the Royal Society of Tropical Medicine and hygiene 88 (1), p. 5-6.
- Haynes, R.K., 2006. From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivates, stereochemistry and medicinal chemistry requirements. Current Topics in Medicinal Chemistry (6), pp. 509-537.
- Haynes, R.K., B. Fugmann, J. Stetter, K. Rieckmann, H.D. Heilmann, H.W. Chan, M.K. Cheung, W.L.
- Lam, H.N. Wong, S.L. Croft, L. Vivas, L. Rattray, L. Stewart, W. Peters, B.L. Robinson, M.D. Edstein, B. Kotecka, D.B. Kyle, B. Beckermann, M. Gerisch, M. Radtke, G. Schmuck, W. Steinke, U. Wollborn, K. Schmeer and A. Romer, 2006. Artemisone – a Highly Active Antimalarial drug of the Artemisinin class. Angewandte Chemie, international edition, Vol. 45 (13), pp: 2082-2088.
- Heemskerk, W., H. Schalling and B. Steenhuijsen Piters, 2006. The world of Artemisia in 44 questions. The Royal Institute (KIT). Kopenhagen.
- Hien, T.T. and N.J. White, 1993. qinghaosu. Lancet 341 (8845), pp. 603-608. Hirt, H.M., 2000.
- Clinical Results of the use of Artemisia annua tea. Available at< http://www.anamed.net/english > [Accessed 1.6.2006].
- Hirt, H.M. 2001. Artemisia annua Anamed. A Plant with Anti-malarial Properties. Anamed – Aktion Natürliche Medizin.
- Hirt, H.M., K. Lindsey and I. Balagizi, 2004. Natural Medicine in the tropics: AIDS and Natural Medicine. Anamed – Aktion Natürliche Medizin.
- Hirt, H.M. and K. Lindsey, 2006a. Artemisia annua Tea – a revolution in the history of tropical medicine – Circular letter. Available at < http://www.anamed.net > [Accessed: 4.6.2006].
- Hirt, H.M. and K. Lindsey, 2006b. Rich Artemisia instead of poor (so-called pure) artemisinin! Available at: < http://www.anamed.net > [Accessed: 4.6.2006].
- Hsu, E., 1999.The transmission of Chinese medicine. Cambridge Univ. Press. Hsu, E., 2001. Innovation in Chinese medicine. Cambridge Univ. Press.
- Hsu, E., 2002. The medicine from China has rapid effects: Chinese medicine patients in Tanzania. Anthropology and Medicine, (9) 3.
- Hsu, E., 2006a. Reflections on the `discovery´ of the antimalarial qinghao. British Journal of Clinical Pharmacology 61 (6), pp. 666-670.
- Hsu, H., 2006b. The History of qinghao in the Chinese materia medica.
- Transactions of the Royal Society of Tropical Medicine and hygiene 100 (6), pp. 505-508.
- Hsu, E., 2009. ‘Diverse Biologies and Experiential Continuities: Did the Ancient Chinese Know that
- Qinghao Had Antimalarial Properties?’ In: Medicine and the Soul of Science: essays by and in Memory of Don Bates. Special issue. Canadian Bulletin of Medical history 26 (1), pp.203-213.
- Kachur, S.P., C. Black, S. Abdulla and C. Goodman , 2006. Putting the genie back in the bottle?
- Availability and presentation of oral Artemisinin compounds at retail pharmacies in urban Dar es Salaam. Malaria Journal (5), p. 25.
- Kamat, V.R., 2006. „I thought it was only ordinary fever!” Cultural knowledge and the micropolitics of therapy seeking for childhood febrile illness in Tanzania. Social Science and Medicine 62 (12), pp. 2945-2959.
- Kamat, V.R., 2009. Cultural interpretations of the efficacy and side effects of antimalarials in Tanzania. Anthropology and Medicine, 16 (3), pp. 293-305.
- Kamat, V.R. and D.J. Nyato, 2010. Community response to Artemisinin-based Combination therapy for childhood malaria: a case study from Dar es Salaam, Tanzania. Malaria Journal (9) 61.
- Klayman, D.L., 1985. Quinghaosu (Artemisinin): An antimalarial drug from China. Science (228), pp.1049-1055.
- Laughlin, J., G. Heazlewood and B. Beattie, 2002. Cultivation of Artemisia annua.34 L. In: Wright C.W. (Ed.): Artemisia. UK. Taylor & Frances.
- Liu, C., Y. Zhao and Y. Wang, 2006. Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug. Applied Microbiological Biotechnology (72), pp.11-20.
- Maregesi, S.M., O.D. Ngassapa, L. Pieters and A.J. Vlientinck, 2007. Ethnopharmacological survey of the Bunda district, Tanzania: plants used to treat infectious diseases. Journal of ethno pharmacology (25), 113 (3), pp.457-470.
- MoH, 2008. Management of Malaria using Combination Therapy. Available at< http//:www.psi.org /tanzania/about.htm > [Accessed: 12.2.2009].
- MSF Medicins Sans Frontiers, 2004. MSF reponds to a shortage of Novartis malaria drug Coartem
- announced by the WHO. Available at [Accessed: 11.2. 2009].
- Mubyazi, G. and M. Gonzalez-Block, 2005. Research influence on antimalarial drug policy change in Tanzania: Case study of replacing chloroquine with sulfadoxine-pyrimethamine as the first-line drug. Malaria Journal 4 (1), pp. 51-63.
- Mueller, M.S., I.B. Karhagomba, H.M. Hirt and E. Wemakor, 2000. The potential of Artemisia annua as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects.
- Journal of ethnopharmacology, (73), pp. 487-493.
- Mutabingwa, T.K., 2005. Artemisinin-based combination therapies (ACTs): Best hope for malaria treatment but inaccessible to the needy! Acta Tropica 95 (3), pp. 305-315.
- NMCP – National Malaria Control Programme, 2007. Africa Malaria Day : Supplement product by the Ministry of Health and Social Welfare. Malaria Day, Dar es Salaam, pp. 1-8.
- NMCP – National Malaria Control Programme, 2008. Management of Malaria using combination therapy. Ministry of Health and Social Welfare.
- United Republic of Tanzania.
- Namdeo, A., K. Mahadik and S. Kadam, 2006. Review article Antimalarial Drug – Artemisia annua. Pharmacognosy Magazine, 2 (6), pp. 106-111.
- Nichter, M., 1992. Ethnomedicine: Diverse trends, common linkeages.
- Anthropological Approaches to the Study of ethnomedicine. Amsterdam: Gordon and Breach Science Publishers.
- Njau, J.D., C.A. Goodman, S. P. Kachur, J. Mulligan, J.S. Munkondya, N. Mchomvu, S. Abdulla, P. Bloland and A. Mills, 2008. The costs of introducing artemisin-based combination therapy: evidence from district-wide implementation in rural Tanzania. Malaria Journal (7) 4.
- Nosten, F. and N.J. White, 2008. Artemisinin-based combination Treatment of Falciparum Malaria. AJTMh, 77 (6), pp. 181-192.
- Novartis, 2010. Coartem in Africa: Gaining Momentum on the Ground. Available at: < http//:www.corporatecitizenship.novartis.com/patients/access-medicines/access-in-practice /coartem-in-africa.shtml > [Accessed: 10.9.2010].
- TechnoServe, 2005. Environmental Impact Assessment of Supporting Artemisia Annua Cultivation in East Africa. Arusha, Tanzania.
- Valecha, N. and K.D. Tripathi, 1997. Artemisinin: Current status in malaria. Indian Journal of Pharmacology (29), pp.71-75.
- Van der Geest, S., S.R. Whyte and A. Hardon, 1996. The Anthropology of pharmaceuticals: a biographical approach. Annual Review of Anthropology (25): 153-178.
- Van der Geest, S. and A. Hardon, 2006. Social and cultural efficacies of medicines: Complications for antiretroviral therapy. Journal of ethnobiology and ethnomedicine (2:48).
- Von Freyhold, M., 2008. Downstream issues Regarding the Production and Distribution of ACTs – Some unanswered and Possibly unorthodox questions. Available at < http://www.mm v.org/iMG/pdf/6_Downstream_issues_for_ACTsM_von_Freyhold.pdf > [Accessed: 4.1.2009].
- Waldram, J.B., 2000. The efficacy of traditional medicine: Current theoretical and methodological issues. Medical Anthropology quarterly 14 (4), pp. 603-625.
- White, N., 2004. Antimalarial drug resistance and combination therapy.
- Philosophical transactions of the royal society. Series B, (354), pp. 739-749. White, N.J., 2008.
- Qinghaosu (Artemisinin): The price of success. Science (320), pp. 330-334.
- Whyte, S.R., S. Van der Geest and A. Hardon, 2002. Social lives of medicines. Cambridge University Press, New York.
- Willcox, M., G. Bodeker, G. Bourdy, V. Dhingra, J. Falquet, J.F.S. Ferreira, B. Graz, H.M. Hirt, E. Hsu, P. Melillo de Magalhaes, D. Provendier and C.W. Wright, 2004. Artemisia annua as a traditional herb antimalarial. In: Willcox, M., G. Bodeker, P. Rasoaniavo, and B. Ranton (Eds.): Traditional Medicinal Plants and Malaria. CRC Press, pp. 43-59.
- Willcox, M., 2009. Artemisia Species: From Traditional Medicines to Modern Antimalarials – and Back Again. Journal of Alternative and Complementary Medicine, 15 (2), pp. 101-109.
- WHO, 2001a. Report of a WHO Technical Consultation on Antimalarial Combination Therapy; Geneva: WHO.
- WHO, 2001b. Antimalarial drug combination therapy. Report of a technical consultation. Geneva: WHO.
- WHO, 2008. World Malaria Report 2008. World Health Organization, Geneva. Wolf, K. and Y. Derriennic, 2005. Costing Artemisinin-based Combination Therapy for Malaria in Tanzania.
- Wright, C., 2002. Artemisia. Taylor & Francis, London.
- Yeung, S., W. Pongtavornpinyo, L.M. Hastings, A.J. Mills and N.J. White, 2004. Antimalarial drug resistance, Artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices. American Journal of Tropical Medicine and hygiene (71), pp. 179-186.
- Yeung, S. and N.J. White, 2005. How do patients use antimalarial drugs?
- Tropical Medicine and international health, 10 (2), pp. 121-138.
- Yu, H.W. and S.M. Zhong, 2002. Artemisia species in traditional Chinese medicine and the discovery of Artemisinin. In: Wright, C.W. (Ed.): Artemisia. London, Taylor & Francis, pp. 149-157.
References
Amin, A.A., D.A. Hughes, V. Marsh, T.O. Abuya, G.O. Kokwaro, P.A. Winstanley, S.A. Ochala and R.W. Snow, 2004. The difference between effectiveness and efficacy of antimalarial drugs in Kenya. Tropical Medicine and international health, 9 (9), pp. 967-974.
Appadurai, A.,1986. The social life of things. Commodities in cultural perspective. Cambridge University Press.
Arrow, K.J., C.B. Panosian and H. Gelband, 2004. Saving lives, buying time: economics of Malaria Drugs in an Age of Resistance. Institute of Medicine of the National Academies, p. 22-23.
Bekanis, A., 2004. Making Artesunate available in African countries. An urgent need. 8. Global Forum for health research, Mexico City, 16-20th November 2004. Pharmacology, Geneva University, Switzerland.
Bhakuni, R.S., D.C. Jain and R.P. Sharma, 2002. Phytochemistry of Artemisia annua and the development of artemisinin-derived antimalarial agents. In: Wright, C.W. (Ed.): Artemisia. London: Taylor & Francis.
Bilia, A.R., D. Lazari, L. Messori, V. Taglioli, C. Temperini and F.F. Vinvieri, 2002.
Simple and Rapid physico-chemical methods to examine action of antimalarial drugs with hemin: its application to Artemisia annua constituents. Life Sciences (70), pp. 769-778.
Bökemeier, R., 2006. Ein Kraut wirkt Wunder. GeO Magazin, Leonardo da vinci (6), 1. 6. 2006.
Bosman, A. and K.N. Mendis, 2007. A major transition in malaria treatment: the adoption and development of Artemisinin-based combination therapies.
American Journal of Tropical Medicine and hygiene (77), pp.193-197.
Chen, J. and T. Chen, 2004. Chinese Medical Herbology and Pharmacology, USA. Art of Medicine Press.
Chetley, A. and D. Gilbert ,1986. Problem Drugs. HAI/IOCU, The Hague/ Penang.
Cutler, M., A. Lapkin, and P.K. Plucinski, 2006. Comparative assessment of technologies for extraction of artemisinin. Summary report commissioned through the Malaria Medicines Venture, Geneva.
Dalrymple, D.G., 2008. Agriculture, Artemisia annua, Artemisinin, ACTs and Malaria control in Africa: The Interplay of Tradition, Science and Public Policy. Workingpaper. Available at < http://artemisia-for-all.org/wordpress/wp-content/uploads/Artemisia_Agr._and_Malaria_in_Afr._ Consolidated no._4-1.pdf > [Accessed 27.4.2010].
De Ridder, S., F. Van der Kooy and R. Verpoorte, 2008. Artemisia annua as a self- reliant treatment for malaria in developing countries. Journal of ethnopharmacology (120), pp. 302-314.
Durrheim, D.N. and H.A. Williams, 2005. Assuring effective malaria treatment in Africa: Drug efficacy is necessary but not sufficient. Journal of epidemiology and Community health (59), pp. 178-189.
Ecks, S., 2008. Global Pharmaceutical Markets and Corporate Citizenship: The Case of Novartis’ Anti-cancer Drug Glivec. BioSocieties 3(2), pp. 165-181.
Etkin, N.L., 1988. Cultural constructions of efficacy. In: Whyte, S.R. and S. Van der Geest (Eds,): The context of medicines in developing countries.
Studies in Pharmaceutical Anthropology 3-11. Amsterdam: Het Spinhuis.
Gessler, M.C., D.E. Msuya, M.H.H. Nkunya, L.B. Mwasumbi, A. Schär, M. Heinrich and M. Tanner, 1995.
Traditional healers in Tanzania: the treatment of malaria with plant materials. Journal of ethno pharmacology (48), pp. 131-144.
Guo-Qiao L., G. Xing-Bo, F. Lin-Chun, J. Hua-Xiang and J. Xin-Hua Wang, 1994. Clinical trials of artemisinin and its derivatives in the treatment of malaria in China. Transactions of the Royal Society of Tropical Medicine and hygiene 88 (1), p. 5-6.
Haynes, R.K., 2006. From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivates, stereochemistry and medicinal chemistry requirements. Current Topics in Medicinal Chemistry (6), pp. 509-537.
Haynes, R.K., B. Fugmann, J. Stetter, K. Rieckmann, H.D. Heilmann, H.W. Chan, M.K. Cheung, W.L.
Lam, H.N. Wong, S.L. Croft, L. Vivas, L. Rattray, L. Stewart, W. Peters, B.L. Robinson, M.D. Edstein, B. Kotecka, D.B. Kyle, B. Beckermann, M. Gerisch, M. Radtke, G. Schmuck, W. Steinke, U. Wollborn, K. Schmeer and A. Romer, 2006. Artemisone – a Highly Active Antimalarial drug of the Artemisinin class. Angewandte Chemie, international edition, Vol. 45 (13), pp: 2082-2088.
Heemskerk, W., H. Schalling and B. Steenhuijsen Piters, 2006. The world of Artemisia in 44 questions. The Royal Institute (KIT). Kopenhagen.
Hien, T.T. and N.J. White, 1993. qinghaosu. Lancet 341 (8845), pp. 603-608. Hirt, H.M., 2000.
Clinical Results of the use of Artemisia annua tea. Available at< http://www.anamed.net/english > [Accessed 1.6.2006].
Hirt, H.M. 2001. Artemisia annua Anamed. A Plant with Anti-malarial Properties. Anamed – Aktion Natürliche Medizin.
Hirt, H.M., K. Lindsey and I. Balagizi, 2004. Natural Medicine in the tropics: AIDS and Natural Medicine. Anamed – Aktion Natürliche Medizin.
Hirt, H.M. and K. Lindsey, 2006a. Artemisia annua Tea – a revolution in the history of tropical medicine – Circular letter. Available at < http://www.anamed.net > [Accessed: 4.6.2006].
Hirt, H.M. and K. Lindsey, 2006b. Rich Artemisia instead of poor (so-called pure) artemisinin! Available at: < http://www.anamed.net > [Accessed: 4.6.2006].
Hsu, E., 1999.The transmission of Chinese medicine. Cambridge Univ. Press. Hsu, E., 2001. Innovation in Chinese medicine. Cambridge Univ. Press.
Hsu, E., 2002. The medicine from China has rapid effects: Chinese medicine patients in Tanzania. Anthropology and Medicine, (9) 3.
Hsu, E., 2006a. Reflections on the `discovery´ of the antimalarial qinghao. British Journal of Clinical Pharmacology 61 (6), pp. 666-670.
Hsu, H., 2006b. The History of qinghao in the Chinese materia medica.
Transactions of the Royal Society of Tropical Medicine and hygiene 100 (6), pp. 505-508.
Hsu, E., 2009. ‘Diverse Biologies and Experiential Continuities: Did the Ancient Chinese Know that
Qinghao Had Antimalarial Properties?’ In: Medicine and the Soul of Science: essays by and in Memory of Don Bates. Special issue. Canadian Bulletin of Medical history 26 (1), pp.203-213.
Kachur, S.P., C. Black, S. Abdulla and C. Goodman , 2006. Putting the genie back in the bottle?
Availability and presentation of oral Artemisinin compounds at retail pharmacies in urban Dar es Salaam. Malaria Journal (5), p. 25.
Kamat, V.R., 2006. „I thought it was only ordinary fever!” Cultural knowledge and the micropolitics of therapy seeking for childhood febrile illness in Tanzania. Social Science and Medicine 62 (12), pp. 2945-2959.
Kamat, V.R., 2009. Cultural interpretations of the efficacy and side effects of antimalarials in Tanzania. Anthropology and Medicine, 16 (3), pp. 293-305.
Kamat, V.R. and D.J. Nyato, 2010. Community response to Artemisinin-based Combination therapy for childhood malaria: a case study from Dar es Salaam, Tanzania. Malaria Journal (9) 61.
Klayman, D.L., 1985. Quinghaosu (Artemisinin): An antimalarial drug from China. Science (228), pp.1049-1055.
Laughlin, J., G. Heazlewood and B. Beattie, 2002. Cultivation of Artemisia annua.34 L. In: Wright C.W. (Ed.): Artemisia. UK. Taylor & Frances.
Liu, C., Y. Zhao and Y. Wang, 2006. Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug. Applied Microbiological Biotechnology (72), pp.11-20.
Maregesi, S.M., O.D. Ngassapa, L. Pieters and A.J. Vlientinck, 2007. Ethnopharmacological survey of the Bunda district, Tanzania: plants used to treat infectious diseases. Journal of ethno pharmacology (25), 113 (3), pp.457-470.
MoH, 2008. Management of Malaria using Combination Therapy. Available at< http//:www.psi.org /tanzania/about.htm > [Accessed: 12.2.2009].
MSF Medicins Sans Frontiers, 2004. MSF reponds to a shortage of Novartis malaria drug Coartem
announced by the WHO. Available at [Accessed: 11.2. 2009].
Mubyazi, G. and M. Gonzalez-Block, 2005. Research influence on antimalarial drug policy change in Tanzania: Case study of replacing chloroquine with sulfadoxine-pyrimethamine as the first-line drug. Malaria Journal 4 (1), pp. 51-63.
Mueller, M.S., I.B. Karhagomba, H.M. Hirt and E. Wemakor, 2000. The potential of Artemisia annua as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects.
Journal of ethnopharmacology, (73), pp. 487-493.
Mutabingwa, T.K., 2005. Artemisinin-based combination therapies (ACTs): Best hope for malaria treatment but inaccessible to the needy! Acta Tropica 95 (3), pp. 305-315.
NMCP – National Malaria Control Programme, 2007. Africa Malaria Day : Supplement product by the Ministry of Health and Social Welfare. Malaria Day, Dar es Salaam, pp. 1-8.
NMCP – National Malaria Control Programme, 2008. Management of Malaria using combination therapy. Ministry of Health and Social Welfare.
United Republic of Tanzania.
Namdeo, A., K. Mahadik and S. Kadam, 2006. Review article Antimalarial Drug – Artemisia annua. Pharmacognosy Magazine, 2 (6), pp. 106-111.
Nichter, M., 1992. Ethnomedicine: Diverse trends, common linkeages.
Anthropological Approaches to the Study of ethnomedicine. Amsterdam: Gordon and Breach Science Publishers.
Njau, J.D., C.A. Goodman, S. P. Kachur, J. Mulligan, J.S. Munkondya, N. Mchomvu, S. Abdulla, P. Bloland and A. Mills, 2008. The costs of introducing artemisin-based combination therapy: evidence from district-wide implementation in rural Tanzania. Malaria Journal (7) 4.
Nosten, F. and N.J. White, 2008. Artemisinin-based combination Treatment of Falciparum Malaria. AJTMh, 77 (6), pp. 181-192.
Novartis, 2010. Coartem in Africa: Gaining Momentum on the Ground. Available at: < http//:www.corporatecitizenship.novartis.com/patients/access-medicines/access-in-practice /coartem-in-africa.shtml > [Accessed: 10.9.2010].
TechnoServe, 2005. Environmental Impact Assessment of Supporting Artemisia Annua Cultivation in East Africa. Arusha, Tanzania.
Valecha, N. and K.D. Tripathi, 1997. Artemisinin: Current status in malaria. Indian Journal of Pharmacology (29), pp.71-75.
Van der Geest, S., S.R. Whyte and A. Hardon, 1996. The Anthropology of pharmaceuticals: a biographical approach. Annual Review of Anthropology (25): 153-178.
Van der Geest, S. and A. Hardon, 2006. Social and cultural efficacies of medicines: Complications for antiretroviral therapy. Journal of ethnobiology and ethnomedicine (2:48).
Von Freyhold, M., 2008. Downstream issues Regarding the Production and Distribution of ACTs – Some unanswered and Possibly unorthodox questions. Available at < http://www.mm v.org/iMG/pdf/6_Downstream_issues_for_ACTsM_von_Freyhold.pdf > [Accessed: 4.1.2009].
Waldram, J.B., 2000. The efficacy of traditional medicine: Current theoretical and methodological issues. Medical Anthropology quarterly 14 (4), pp. 603-625.
White, N., 2004. Antimalarial drug resistance and combination therapy.
Philosophical transactions of the royal society. Series B, (354), pp. 739-749. White, N.J., 2008.
Qinghaosu (Artemisinin): The price of success. Science (320), pp. 330-334.
Whyte, S.R., S. Van der Geest and A. Hardon, 2002. Social lives of medicines. Cambridge University Press, New York.
Willcox, M., G. Bodeker, G. Bourdy, V. Dhingra, J. Falquet, J.F.S. Ferreira, B. Graz, H.M. Hirt, E. Hsu, P. Melillo de Magalhaes, D. Provendier and C.W. Wright, 2004. Artemisia annua as a traditional herb antimalarial. In: Willcox, M., G. Bodeker, P. Rasoaniavo, and B. Ranton (Eds.): Traditional Medicinal Plants and Malaria. CRC Press, pp. 43-59.
Willcox, M., 2009. Artemisia Species: From Traditional Medicines to Modern Antimalarials – and Back Again. Journal of Alternative and Complementary Medicine, 15 (2), pp. 101-109.
WHO, 2001a. Report of a WHO Technical Consultation on Antimalarial Combination Therapy; Geneva: WHO.
WHO, 2001b. Antimalarial drug combination therapy. Report of a technical consultation. Geneva: WHO.
WHO, 2008. World Malaria Report 2008. World Health Organization, Geneva. Wolf, K. and Y. Derriennic, 2005. Costing Artemisinin-based Combination Therapy for Malaria in Tanzania.
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